研究・業績｜医局紹介 | 東京医科大学高齢診療科

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医局紹介
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研究・業績

　高齢総合医学の目標は高齢者のADL、QOLを維持・向上させ、健康寿命を延伸させることです。しかし、高齢者では認知症、フレイル（高齢者の虚弱状態）、嚥下障害、転倒などの老年症候群がこの目標の達成を阻んでいます。当教室では老年症候群に対してその評価や成因解明に始まり、最終的には予防法、治療法、介護法の開発や個々の高齢者のトータルケアに取り組んでいます。
　この老年症候群に対する研究成果を活用し、その成果を多職種との連携で応用・実践しています。既に始まっているこの高齢化社会を、高齢者が活き活きと過ごせる活力あるものにすべく、当教室は貢献しつづけて参ります。

・高齢認知症患者の身体合併症の調査と包括的診療に関する研究
・アルツハイマー病における脳神経病理および分子遺伝学的検索
・高齢認知症や脳血管障害患者の酸化ストレスに関する研究
・糖尿病性認知症の病態解明研究
・レビー小体型認知症における脳神経病理、生化学、脳機能画像による病態解明研究
・高齢認知症患者の介護負担に関する研究
・高齢者うつ病の画像解析および病態解明研究
・高齢者総合的機能評価CGA(Comprehensive Geriatric Assessment）の開発と解析
・フレイルおよび高齢者栄養管理に関する調査研究と予防法の開発
・高齢者のサルコペニアの病態学的研究
・脳血管障害の成因に関する脳神経病理およびMRI画像の研究

2021

1）	Sato T, Hanyu H, Koyama Y, Horita H, Aoki T, Hirao K, Kanetaka H, Shimizu S. Discrepancy Between the Degree of Cognitive Impairment and Brain Imaging Abnormalities in Alzheimer's Disease Patients Is Associated with Cognitive Reserve. J Alzheimers Dis. 2021; 84(1):273-281.
2）	Hirao K, Yamashita F, Sakurai S, Tsugawa A, Haime R, Fukasawa R, Sato T, Kanetaka H, Umahara T, Sakurai H, Hanyu H, Shimizu S. Association of regional white matter hyperintensity volumes with cognitive dysfunction and vascular risk factors in patients with amnestic mild cognitive impairment. Geriatr Gerontol Int. 2021;21(8):644-650.
3）	Ogata J, Hirao K, Nishioka K, Hayashida A, Li Y, Yoshino H, Shimizu S, Hattori N, Imai Y. A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson's Disease Affects LRRK2 Protein Levels. Int J Mol Sci. 2021 Apr 2;22(7):3708.
4）	Hirao K, Yamashita F, Tsugawa A, Haime R, Fukasawa R, Sato T, Kanetaka H, Umahara T, Sakurai H, Hanyu H, Shimizu S. Association of White Matter Hyperintensity Progression with Cognitive Decline in Patients with Amnestic Mild Cognitive Impairment. J Alzheimers Dis. 2021;80(2):877-883.
5）	Inagawa Y, Shimizu S, Takenoshita N, Tsugawa A, Hirose D, Kanbayashi T, Imanishi A, Sakurai H, Hanyu H, Kanetaka H, Hirao K. Association between cerebrospinal fluid Orexin A level and severity of rapid eye movement sleep behaviour disorder in dementia with Lewy bodies. Psychogeriatrics. 2021 Jan;21(1):128-130.

2020

1）	Umahara T, Uchihara T, Hirao K, Shimizu S, Hashimoto T, Kohno M, Hanyu H. Essential autophagic protein Beclin 1 localizes to atherosclerotic lesions of human carotid and major intracranial arteries. J Neurol Sci. 2020 Apr 13;414
2）	Kaneko Y, Hirao K, Serisawa S, Kanetaka H, Shimizu S, Hirai H, Shishido-Hara Y, Umahara T, Sakurai H, Hanyu H. Association between clinical symptoms and post-mortem neuropathology in dementia with Lewy bodies. Geriatr Gerontol Int. 2020 Mar;20(3):261-26
3）	Tsugawa A, Shimizu S, Hirose D, Sato T, Hatanaka H, Takenoshita N, Kaneko Y, Ogawa Y, Sakurai H, Hanyu H. Effects of 12-month exercise intervention on physical and cognitive functions of nursing home residents requiring long-term care: a non-randomised pilot study. Psychogeriatrics. 2020 Feb 4.
4）	Shimizu S, Takenoshita N, Inagawa Y, Tsugawa A, Hirose D, Kaneko Y, Ogawa Y, Serisawa S, Sakurai S, Hirao K, Kanetaka H, Kanbayashi T, Imanishi A, Sakurai H, Hanyu H. Positive Association Between Cognitive Function and Cerebrospinal Fluid Orexin A Levels in Alzheimer's Disease. J Alzheimers Dis.
5）	Umahara T, Uchihara T, Hirao K, Shimizu S, Hashimoto T, Akimoto J, Kohno M, Hanyu H. Frontotemporal dementia-associated protein "phosphorylated TDP-43" localizes to atherosclerotic lesions of human carotid and main cerebral arteries. Histol Histopathol. 2020 Feb;35(2):159-167.
6）	Umahara T, Uchihara T, Hirao K, Shimizu S, Hanyu H. Phosphorylated TDP-43 localizes to chronic cerebral infarctions in human brains. Histol Histopathol. 2020 Jun 18:18235.
7）	Serisawa S, Hirao K, Sato T, Ogawa Y, Kanetaka H, Enomoto M, Shimizu S, Sakurai H, Sakashita Y, Murayama S, Hanyu H. Adult-onset neuronal intranuclear inclusion disease showing markedly high phosphorylated tau protein levels in cerebrospinal fluid. Geriatr Gerontol Int. 2020 Aug;20(8):793-795.
8）	Tsugawa A, Sakurai S, Inagawa Y, Hirose D, Kaneko Y, Ogawa Y, Serisawa S, Takenoshita N, Sakurai H, Kanetaka H, Hirao K, Shimizu S. Awareness of the COVID-19 Outbreak and Resultant Depressive Tendencies in Patients with Severe Alzheimer's Disease. J Alzheimers Dis. 2020;77(2):539-541.
9）	Inagawa Y, Kanetaka H, Tsugawa A, Sakurai S, Serisawa S, Shimizu S, Sakurai H, Hanyu H. Efficacy of Olfactory and Pareidolia Tests Compared With That of Indicative Biomarkers in Diagnosis of Dementia With Lewy Bodies. Front Neurol. 2020 Sep 11;11:540291.

2019

1）	Takenoshita N, Shimizu S, Fukasawa R, Sato T, Kanetaka H, Sakurai H, Ishii K, Hanyu H. Amyloid burden in diabetes-related dementia. Geriatr Gerontol Int. 2019 Oct;19(10):1066-1068.
2）	Matsuda H, Yokoyama K, Sato N, Ito K, Nemoto K, Oba H, Hanyu H, Kanetaka H, Mizumura S, Kitamura S, Shinotoh H, Shimada H, Suhara T, Terada H, Nakatsuka T, Kawakatsu S, Hayashi H, Asada T, Ono T, Goto T, Shigemori K. Differentiation Between Dementia With Lewy Bodies And Alzheimer's Disease Using Voxel-Based Morphometry Of Structural MRI: A Multicenter Study. Neuropsychiatr Dis Treat. 2019 Sep 19;15:2715-2722.
3）	Hirao K, Yamashita F, Tsugawa A, Haime R, Fukasawa R, Sato T, Okita M, Shimizu S, Kanetaka H, Umahara T, Sakurai H, Hanyu H. Association of serum cystatin C with white matter abnormalities in patients with amnestic mild cognitive impairment. Geriatr Gerontol Int. 2019 Oct;19(10):1036-1040.
4）	Takenoshita N, Shimizu S, Kanetaka H, Sakurai H, Suzuki R, Miwa T, Odawara M, Ishii K, Shimada H, Higuchi M, Suhara T, Hanyu H. Classification of Clinically Diagnosed Alzheimer's Disease Associated with Diabetes Based on Amyloid and Tau PET Results. J Alzheimers Dis. 2019;71(1):261-271.
5）	Furumi Y, Shimizu S, Ogawa Y, Hirose D, Takada Y, Kanetaka H, Sakurai H, Mae A, Hanyu H. [A suspicious case of coagulation disorder caused by vitamin K deficiency associated with fasting and antibiotics]. Nihon Ronen Igakkai Zasshi. 2019;56(2):204-208.
6)	Hanyu H. Diabetes-Related Dementia. Adv Exp Med Biol. 2019;1128:147-160.
7）	Hirose D, Shimizu S, Hirao K, Ogawa Y, Sato T, Kaneko Y, Takenoshita N, Namioka N, Fukasawa R, Umahara T, Sakurai H, Watanabe R, Hanyu H. Neuroimaging Characteristics of Frailty Status in Patients with Alzheimer's Disease. J Alzheimers Dis. 2019;67(4):1201-1208.
8）	Ogawa Y, Shimizu S, Takenoshita N, Kaneko Y, Satoto T, Hanyu H. Ambulatory glucose profile in diabetes-related dementia. Geriatr Gerontol Int. 2019 Apr;19(4):282-286.

2018

1）	Hirao K, Kaneko Y, Hirose D, Fukasawa R, Shimizu S, Kanetaka H, Umahara T, Sakurai H, Hanyu H. Patient with Parkinson's disease presenting with impulse control disorders following treatment with selegiline. Int Psychogeriatr. 2018 Dec 6:1-2.
2）	Toyoshima K, Araki A, Tamura Y, Iritani O, Ogawa S, Kozaki K, Ebihara S, Hanyu H, Arai H, Kuzuya M, Iijima K, Sakurai T, Suzuki T, Toba K, Arai H, Akishita M, Rakugi H, Yokote K, Ito H, Awata S. Development of the Dementia Assessment Sheet for Community-based Integrated Care System 8-items, a short version of the Dementia Assessment Sheet for Community-based Integrated Care System 21-items, for the assessment of cognitive and daily functions. Geriatr Gerontol Int. 2018 Oct;18(10):1458-1462.
3）	Ogawa Y, Kaneko Y, Sato T, Shimizu S, Kanetaka H, Hanyu H. Sarcopenia and Muscle Functions at Various Stages of Alzheimer Disease. Front Neurol. 2018 Aug 28;9:710.
4）	Terayama H, Sakurai H, Namioka N, Jaime R, Otakeguchi K, Fukasawa R, Sato T, Hirao K, Kanetaka H, Shimizu S, Umahara T, Hanyu H. Caregivers' education decreases depression symptoms and burden in caregivers of patients with dementia. Psychogeriatrics. 2018 Sep;18(5):327-333.
5）	Takenoshita N, Fukasawa R, Ogawa Y, Shimizu S, Umahara T, Ishii K, Shimada H, Higuchi M, Suhara T, Hanyu H. Amyloid and Tau Positron Emission Tomography in Suggested Diabetesrelated Dementia. Curr Alzheimer Res. 2018;15(11):1062-1069.
6）	Komatsu J, Samuraki M, Nakajima K, Arai H, Arai H, Arai T, Asada T, Fujishiro H, Hanyu H, Iizuka O, Iseki E, Kashihara K, Kosaka K, Maruno H, Mizukami K, Mizuno Y, Mori E, Nakamura H, Nakano S, Nakashima K, Nishio Y, Orimo S, Takahashi A, Taki J, Tokuda T, Urakami K, Utsumi K, Wada K, Washimi Y, Yamashina S, Yamasaki J, Yoshita M, Yamada M. 123I-MIBG myocardial scintigraphy for the diagnosis of DLB: a multicentre 3-year follow-up study.J Neurol Neurosurg Psychiatry. 2018 Nov;89(11):1167-1173.
7）	Shimizu S, Hirose D, Hatanaka H, Takenoshita N, Kaneko Y, Ogawa Y, Sakurai H, Hanyu H. Role of Neuroimaging as a Biomarker for Neurodegenerative Diseases. Front Neurol. 2018 Apr 18;9:265.
8）	Wakabayashi K, Umahara T, Hirokawa K, Hanyu H, Uchihara T. 14-3-3 protein sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease. Neurosci Lett. 2018 May 1;674:171-175.
9）	Shimizu S, Imabayashi E, Takenoshita N, Okamura N, Furumoto S, Kudo Y, Matsuda H, Hanyu H. Case of progressive supranuclear palsy detected by tau imaging with [18 F]THK-5351 before the appearance of characteristic clinical features. Geriatr Gerontol Int. 2018 Mar;18(3):501-502.
10）	Hanyu H. [Prevention of Dementia-with Special Reference to Lifestyle and Vascular Risk Factors]. Brain Nerve. 2018 Mar;70(3):191-198.
11)	Yamakawa H, Okita M, Fukasawa R, Hatanaka H, Namioka N, Hanyu H. A comparison between the Mini-Mental State Examination and Montreal Cognitive Assessment in assessing cognitive function in patients with diabetes-related dementia. Psychogeriatrics. 2018 Jan;18(1):72-73.
12）	Umahara T, Uchihara T, Hirokawa K, Hirao K, Shimizu S, Hashimoto T, Terasi H, Hanyu H. Time-dependent and lesion-dependent HMGB1-selective localization in brains of patients with cerebrovascular diseases. Histol Histopathol. 2018 Feb;33(2):215-222.

2017

1）	Tsugawa A, Ogawa Y, Takenoshita N, Kaneko Y, Hatanaka H, Jaime E, Fukasawa R, Hanyu H. Decreased Muscle Strength and Quality in Diabetes-Related Dementia. Dement Geriatr Cogn Dis Extra. 2017 Dec 22;7(3):454-462.
2）	Kanetaka H, Fukasawa R, Shimizu S, Takenoshita N, Hanyu H. Cerebrospinal fluid analysis in individuals with diabetes-related dementia. eNeurologicalSci. 2017 Jun 13;8:9-10.
3）	Hirose D, Hirao K, Kaneko Y, Fukasawa R, Sato T, Shimizu S, Kanetaka H, Umahara T, Sakurai H, Yoneda M, Hanyu H. Case of Hashimoto's encephalopathy showing atypical clinical course with magnetic resonance imaging abnormalities. Geriatr Gerontol Int. 2017 Aug;17(8):1235-1237.
4）	Hirao K, Hirose D, Fukasawa R, Takata Y, Shimizu S, Kanetaka H, Umahara T, Sakurai H, Hanyu H. A sporadic case of Creutzfeldt-Jakob disease showing unilateral hemispheric involvement on magnetic resonance imaging. Psychogeriatrics. 2017 Nov;17(6):517-519.
5）	Hatanaka H, Hirose D, Hirao K, Shimizu S, Kanetaka H, Hanyu H. Longitudinal changes in peripheral oxidative markers in patients with Alzheimer's disease, with or without cardiovascular disease. Geriatr Gerontol Int. 2017 Jun;17(6):1035-1037.
6）	Hashimoto Y, Umahara T, Hanyu H, Iwamoto T, Matsuoka M. Calmodulin-like skin protein is downregulated in human cerebrospinal fluids of Alzheimer's disease patients with apolipoprotein E4; a pilot study using postmortem samples. Neurol Res. 2017 Sep;39(9):767-772.
7）	Shimizu S, Namioka N, Hirose D, Kanetaka H, Hirao K, Hatanaka H, Takenoshita N, Kaneko Y, Ogawa Y, Tsugawa A, Umahara T, Sakurai H, Hanyu H. Comparison of diagnostic utility of semi-quantitative analysis for DAT-SPECT for distinguishing DLB from AD. J Neurol Sci. 2017 Jun 15;377:50-54.
8）	Shimizu S, Hirose D, Namioka N, Kanetaka H, Hirao K, Hatanaka H, Takenoshita N, Kaneko Y, Ogawa Y, Umahara T, Sakurai H, Hanyu H. Correlation between clinical symptoms and striatal DAT uptake in patients with DLB. Ann Nucl Med. 2017 Jun;31(5):390-398.
9）	Hirose D, Hanyu H, Fukasawa R, Namioka N, Hatanaka H, Sato T. Diabetes-related dementia is associated with dynapenia, but not with sarcopenia. Geriatr Gerontol Int. 2017 Jan;17(1):175-177.
10）	Namioka N, Sakurai H, Terayama H, Iwamoto T, Fujihira T, Tsugehara H, Tsuchida A, Hanyu H. Geriatric problems correlated with cognitive decline using a screening test named "Dr. SUPERMAN" for comprehensive geriatric assessment in elderly inpatients. Geriatr Gerontol Int. 2017 Sep;17(9):1252-1256.
11)	Namioka N, Hanyu H, Hirose D, Hatanaka H, Sato T, Shimizu S. Oxidative stress and inflammation are associated with physical frailty in patients with Alzheimer's disease. Geriatr Gerontol Int. 2017 Jun;17(6):913-918.
12）	Shimizu S, Kanetaka H, Hirao K, Fukasawa R, Namioka N, Hatanaka H, Hirose D, Umahara T, Sakurai H, Hanyu H. Neuroimaging for diagnosing dementia with Lewy bodies: What is the best neuroimaging technique in discriminating dementia with Lewy bodies from Alzheimer's disease? Geriatr Gerontol Int. 2017 May;17(5):819-824.
13）	Shimizu S. Author's reply "What is the best neuroimaging technique in discriminating dementia with Lewy bodies from Alzheimer's disease?" Geriatr Gerontol Int. 2017 May;17(5):858-859.